This book provides bibliographic information, ownership records, a detailed worldwide census and a description of the handwritten annotations for all the surviving copies of the 1543 and 1555 editions of Vesalius’ De humani corporis fabrica. It also offers a groundbreaking historical analysis of how the Fabrica traveled across the globe, and how readers studied, annotated and critiqued its contents from 1543 to 2017. The Fabrica of Andreas Vesalius sheds a fresh light on the book’s vibrant reception history and documents how physicians, artists, theologians and collectors filled its pages with copious annotations. It also offers a novel interpretation of how an early anatomical textbook became one of the most coveted rare books for collectors in the 21st century.